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Generic cymbalta in us 2007 - http://www.ncbi.nlm.nih.gov/pubmed/16749471#F Cymbalta in clinical trials does not decrease suicidal intent or behaviors. http://www.ncbi.nlm.nih.gov/pubmed/19968985#F Antidepressant:Cymbalta Postmarketing reports: The efficacy and safety of cymbalta, an antidepressant, were confirmed in two randomized, double-blind, placebo-controlled trials.[10-12] Cymbalta was used as an adjunct to psychotherapy for mild moderate depression. The treatment was superior to placebo in reducing the number of depressive episodes.[9,10-12] Cymbalta also showed improvements in best price on cymbalta sleep, quality of life, and general generic online pharmacy uk distress. These benefits, however, were not maintained long-term. At the end of treatment, patients showed significant depression relapse. It is important to note that the number of patients enrolled and the duration of treatment in these trials were small and that the patients in two trials reported more treatment-emergent adverse events. Clinical trials vs. non-clinical There have been several non-clinical studies comparing cymbalta generic cost Cymbalta to placebo, as well randomized clinical trials (RCTs) of Cymbalta.[13,14] A Cochrane review was done, which looked at the efficacy of Cymbalta compared to placebo and standard antidepressants. This Cochrane review did not include placebo-controlled trials and thus conclusions are limited.[13,14] Other side effects Symptoms of Cymbalta toxicity can include decreased appetite, dizziness, nausea, vomiting, headache, muscle and bone pain, insomnia, nausea, diarrhea, dizziness, and confusion. Patients may become drowsy, feel cold, and sweat. Symptoms can be severe. Discontinuation symptoms Cymbalta can occasionally cause severe withdrawal symptoms (for more information see Cymbalta Toxicosis) with very heavy treatment regimens. Treatment-emergent adverse experiences (TEAEs) Common adverse events (AEs) reported in clinical trials of Cymbalta are diarrhea, insomnia, headache, nausea, restlessness, sweating, difficulty concentrating, muscle fatigue, rash, nausea, abdominal pain, and sweating. Dosage In general, Cymbalta is taken only as needed with physician supervision and the following maximum doses durations may be exceeded: Dosing for depression in adults: 10 mg/day orally over 6 consecutive days for 10 weeks.[15] Treatment for depression in children: 100 to 400 mg orally once daily for 8 weeks, then discontinued.[15] Contraindications Pregnancy Animal reproduction studies have not been conducted with Cymbalta. It is not known whether Cymbalta passes into human breast milk and if so whether this distribution may affect milk-formulated products. Because Cymbalta is classified as a Schedule IV controlled substance, the possibility of an interaction between Cymbalta and breastfeeding has not been evaluated. Pediatric use and/or lack of effectiveness There is no data on the safety and effectiveness of Cymbalta in pediatric patients aged 6 to 17 years. Because Cymbalta is classified as a Schedule IV controlled substance, the possibility of an interaction between Cymbalta and pediatric use has not been evaluated. Interactions The following adverse reaction(s) have been associated with Cymbalta use: Adverse reactions associated with cyclobenzaprine CYP450 3A4 isoenzymes 1A2 2D6 Non-CYP450 3A4 isoenzymes CYP450 inhibitors Cyproheptadine and pimozide are not cyproheptadine-specific. Diclofenac will increase clearance of other CYP450 3A4 inhibitors and is not specific for CYP450 3A4 inhibitors.[16][17] Other interactions Cymbalta may decrease the plasma concentration of some other medications, including: Cyproheptadine Pimozide Progesterone Cyproheptadine is poorly absorbed. It has been estimated that the mean daily concentration of cyproheptadine in plasma after 4 weeks of dosing was ~1000 ng/mL/mL (range: <200 ng/mL to >1500 ng/mL).[18]

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Cymbalta is an antidepressant. It is used to treat depression. It is also used to treat pain caused by complications of diabetes or pain caused by fibromyalgia.



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